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KMID : 1059519900340020203
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Journal of the Korean Chemical Society
1990 Volume.34 No. 2 p.203 ~ p.210
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Studies on Synthesis of Block Copolymers Containing Polyester and Polypeptide for Drug Delivery System Ⅰ. Synthesis and Characterization of Copolymer of L-Lactic Acid and L-Glutamic Acid
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Kim Hong-Beom
Sung Yong-Kiel
Jung Jae-Hee
Baik Hyung-Gee
Min Tae-Jin
Kim Young-Soon
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Abstract
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As a possible biocompatible and biodegrable polymer skeleton for drug delivery system, block copolymers of L-lactic acid and L-glutamic acid with different composition were synthesized and characterized. Poly (L-lactide) was prepared by polymerization of L-lactide with zine oxide at 130℃ for 72 hrs. 3-Amino-l-propanol was introduced to poly (L-lactide) by an ester linkage in order to initiate polymerization. Polymerization of γ-benzyl-L-glutamate-N-carboxyanhydride (γ-BLG-NCA) utiliizing the amino group of modified poly (L-lactide) as an initiator gave rise to the block copoly (L-lactide-γ-benzyl-L-glutamate). The NMR study of resulting block copolymers showed that the composition of L-lactic acid and γ-benzyl-L-glutamate in block copolymers was depended on the weight ratio of poly (L-lactide) and γ-BLG-NCA. The thermal properties of the resulting block copolymers were determined by the differential scanning calorimetry and by the thermogravimetry.
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